Polyol and sugar osmolytes can shorten protein hydrogen bonds to modulate function
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چکیده
منابع مشابه
Contribution of hydrogen bonds to protein stability.
Our goal was to gain a better understanding of the contribution of the burial of polar groups and their hydrogen bonds to the conformational stability of proteins. We measured the change in stability, Δ(ΔG), for a series of hydrogen bonding mutants in four proteins: villin headpiece subdomain (VHP) containing 36 residues, a surface protein from Borrelia burgdorferi (VlsE) containing 341 residue...
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The hydrogen bond plays an essential role in maintaining the secondary structures of protein, and an accurate description of hydrogen bond interaction is critical in protein folding simulation. Modern classical force fields treat hydrogen bonding as nonbond‐ ed interaction, which is dominated by electrostatic interaction. However, in the widely used nonpolarizable force fields, atomic charges a...
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Finding the structure of proteins and protein-protein complexes is an important problem in the field of computational biology. Determining protein structures can be done successfully with various experimental methods like x-ray crystallography, but determining protein-protein structures experimentally is more difficult. Instead, these structures are frequently predicted computationally. One app...
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ژورنال
عنوان ژورنال: Communications Biology
سال: 2020
ISSN: 2399-3642
DOI: 10.1038/s42003-020-01260-1